smtp.louisville.edu is no longer going to work outside of the UofL network. It is considered non-standard email practice and sanctioned "spoofling".
We are encouraging people to use the outlook web client or Outlook 2016.
If you haven't migrated to Office365 yet, go to
exchange.louisville.edu
and log in with his userid and password.
After migration, go to
outlook.office365.com
and log in with
userid@louisville.edu
and the regular password
Please let us know if we can provide any other assistance.